The College of Science at the University of Basrah organized a seminar (Investigation of Immunological and Microbial Biomarkers Associated with Allergic Skin Disease) by the graduate student Shahd Shihab Ahmed the study aims the principal objective of this study is to investigate the impact of particular immunological markers on the development of urticaria and to evaluate their association with microbial skin infections for causing urticaria, Basrah province, Iraq. and included 1. Evaluation of immunological responses through the quantification of serum concentrations of IL-33, IgD, Progranulin, and Human β-defensin 2. 2. Isolation and identification of the cutaneous microbiota in individuals with urticaria and the study was recommended 1. Additional research is advised to explore the involvement of other immune-related variables, including granulin and progranulin, and to elucidate their relationship with chronic urticaria.

2. Subsequent investigations should assess the role of supplementary innate immune elements, specifically cathelicidin LL-37, in the aetiology of chronic urticaria.

3. Additional molecular investigations are advised to examine the genetic traits of the skin microbiota and their correlation with sex chromosomes in both genders, to elucidate their possible link to chronic urticaria.

4. It is advisable to conduct gene expression studies to evaluate the expression levels of IL-33, β-defensins, IgD, and progranulin as prospective biomarkers in chronic urticaria.