The College of Science discussed a Ph.D. thesis about the Synthesis, Characterization, and Biochemical Evaluation of Novel Simvastatin Derivatives

by Amaal Hussein Sheaa

The thesis aimed to synthesize six novel simvastatin derivatives by introducing short-chain aliphatic carboxylic acid moieties, structurally confirmed using FTIR, ¹H-NMR, ¹³C-NMR, and Mass spectrometry. Acute oral toxicity (LD₅₀) evaluation revealed high safety with no mortality, while biocompatibility assays on normal human cells showed no significant cytotoxicity.

Four derivatives were selected for in vivo assessment in a hypercholesterolemic rat model. Therapeutic efficacy was evaluated through lipid profile analysis, liver and kidney function tests, and HMG-CoA reductase concentration, complemented by histopathological examinations of liver and kidney tissues.