Ph.D thesis at the Collage of Science - University of Basrah (Molecular Immunology of Celiac Disease in Thi-Qar province - South of Iraq), and showed the researcher's thesis (Safaa Hussein Abdullah). Thesis aims includes the using of two steps testing approach for serological diagnosis of CD is a quite precise strategy for the diagnosis of suspicious persons and can be a potent marker for monitoring the activity of this disease and the current study suggests that polymorphism in the CD28 +17T/C (rs3116496) SNP is not a genetic risk factor for CD in the Thi-Qar population, or that it has a weak effect undetectable in these samples, and for CTLA4 +49A/G (rs231775) SNP is a genetic risk factor for CD and quite effect detect in these samples.