Cytochrome p4502D6 Gene Polymorphisms with Bowel Diseases in human and showed the researcher's thesis Ghada thaer mohammed . The study aimed to investigate the association between genetic polymorphisms of the CYP2D6, NOD2, GSTM1, and GSTT1genes and the risk of inflammatory bowel disease (IBD).and included The study included 100 blood samples from patients with inflammatory bowel disease (Crohn’s disease and ulcerative colitis) and 100 blood samples from healthy individuals who served as the control group. The participants ranged in age from 8 to 88 years, and demographic and clinical data were collected for all participants.and the study was recommende Conduct studies with larger sample sizes and from multiple geographic regions to increase the statistical power and validate the associations between CYP2D6, NOD2, GSTM1, and GSTT1 polymorphisms and inflammatory bowel disease (IBD).