The College of Science at the University of Basrah organized a seminar entitled (Systemic Physiological Dysregulation in Intestinal Inflammatory Disorders ) by the graduate student Nakaa Qassim Ghali The study aims Highlight the primary types of Inflammatory Bowel Disease (IBD), understand the pathophysiological mechanisms and intestinal barrier dysfunction, and review modern trends in management and treatment and included discussion on the etiology and genetic and environmental risk factors, the impact of the "Brain-Gut Axis," and an analysis of global epidemiological data regarding the prevalence and progression of the disease.