The College of Science at University of Basrah organized a seminar entitled (Immunological Microenvironment During Endometrial Carcinoma) by the graduate student Zainab Waleed Abd-Alkhaleeq Al-Ameer. The study aims to investigates the impact of the endometrial tumor microenvironment on the immune response. It aims to determine how this microenvironment influences immune cell mechanisms and contributes to tumor progression. The findings likely highlight the complex interactions between tumor cells and immune cells, revealing that the tumor microenvironment can modulate immune cell activity, potentially leading to enhanced tumor growth and included explaining endometrial cancer and the most important causes, diagnostic methods, and available treatment methods for this disease, with a focus on understanding the mechanisms of response against the tumor in the endometrial environment. Which in turn will contribute to the development of immunotherapies for endometrial cancer patients.