A master's thesis in the College of Science at the University of Basrah was discussed (Expression of Fibronectin and MMP-1 in Breast cancer patients in Basrah Province), and showed or included the researcher's thesis (Zainab Abdul-Wahid Shayea) to identify one of the extracellular matrix proteins, which is the FN protein, fibronectin, and its relationship to the stimulation of one of the enzymes of matrixmetalloproteinase, which is MMP-1, as well as exploring the expression of fibronectin protein and its clinical significance in breast cancer patients, as well as exploring its relationship to the MMP-1 enzyme by measuring their levels in the serum and tissue of breast cancer patients. High levels of MMP-1 in patients with malignant comparing with benign breast tumor. High levels of fibronectin in the serum of both benign and malignant breast tumor patients, high expression of fibronectin in the tissue of patients with benign and malignant breast tumors, as well as for the MMP-1 enzyme .... She recommended conducting further studies on other types of fibronectin and comparing its expression with other types of breast cancer. MMPs family as well as an immunological study to understand the mechanism of degradation of extraceular matrix.