Zainab Kadhim Zbala Al-Khazragie and Prof. Dr. Adnan J. M. Al-Fartosy and Prof. Dr. Bushra K. Al-Salami published a paper entitled (Synthesis, characterization and biological Activity of β-Lactam and Thiazolidinone Derivatives Based on Sulfonamide) in the Egyptian Journal of Chemistry, which is indexed in Scopus (Q3) database. The study aims to synthesis of a series of sulfonamide schiff bases by the condensation reaction of sulfonamides with vanillin and salicylaldehyde, respectively in an acidic medium. These Schiff bases were used to a new series of β-lactam compounds by their reactions with thioglycolic acid and 2-selenoglycolic acid, respectively, in presences of phosphorus oxychloride POCl3 and triethylamine. Cyclocondensation of the Schiff bases with 2-mercaptobutanoic acid in presence of zinc chloride afforded 4-thiazolidinone derivatives. The results pointed that the β-lactam compounds containing selenium were less toxic than its analogues containing sulphur based on the LD50 value. Some synthesized compounds showed antibacterial properties and studied compounds showed a good antioxidant activity but at a lower rate than the standard compound BHT. Our results obviously revealed that β-lactam compound containing sulphur had possess a strong activity with good IC50 against human breast cancer MCF-7 cells at a higher rate than the standard compound 5-fluorouracil.